Literature summary for 2.7.10.2 extracted from

Witthuhn, B.A.; Silvennoinen, O.; Miura, O.; Lai, K.S.; Cwik, C.; Liu, E.T.; Ihle, J.N.
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells (1994), Nature, 370, 153-157.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor beta-chain, but does not require the acidic domain that is required for association and activation of Src family kinases	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q62137	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
Jak-3 Janus kinase	-	Mus musculus
tyrosine-protein kinase JAK3	-	Mus musculus

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Release 2023.1 (January 2023)