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Literature summary for 2.7.10.1 extracted from

  • Lim, C.; Oh, K.; Ha, J.; Lee, J.; Seo, H.; Chae, C.; Kim, D.; Lee, M.; Lee, B.
    4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors (2014), Bioorg. Med. Chem. Lett., 24, 4080-4083.
    View publication on PubMed
Search for more literature for 2.7.10.1

Inhibitors

Inhibitors Comment Organism Structure
6-methoxy-7-[(morpholin-2-yl)methoxy]-N-(4-propylphenyl)quinazolin-4-amine
-
 Homo sapiens
N-(3,5-dichlorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(3-bromophenyl)-6-methoxy-7-[(4-methylmorpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(3-bromophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(3-chloro-4-methylphenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(3-chlorophenyl)-6-methoxy-7-[(4-methylmorpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(3-chlorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-bromo-2-chlorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-bromo-3-methylphenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-bromophenyl)-6-methoxy-7-[(4-methylmorpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-bromophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-fluoro-2-methylphenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-(4-fluorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-[4-chloro-3-(trifluoromethyl)phenyl]-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
N-[4-fluoro-3-(trifluoromethyl)phenyl]-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
-
 Homo sapiens
tert-butyl 2-([[4-(3-bromoanilino)-6-methoxyquinazolin-7-yl]oxy]methyl)morpholine-4-carboxylate
-
 Homo sapiens
tert-butyl 2-([[4-(3-chloroanilino)-6-methoxyquinazolin-7-yl]oxy]methyl)morpholine-4-carboxylate
-
 Homo sapiens
tert-butyl 2-([[4-(4-bromoanilino)-6-methoxyquinazolin-7-yl]oxy]methyl)morpholine-4-carboxylate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
EphA2
-
 Homo sapiens
erythropoietin-producing hepatocellular receptor tyrosine kinase subtype A2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00016
-
 pH and temperature not specified in the publication Homo sapiens N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00017
-
 pH and temperature not specified in the publication Homo sapiens N-[4-chloro-3-(trifluoromethyl)phenyl]-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.0002
-
 pH and temperature not specified in the publication Homo sapiens N-(4-fluoro-2-methylphenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00023
-
 pH and temperature not specified in the publication Homo sapiens N-(4-bromo-2-chlorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.0003
-
 pH and temperature not specified in the publication Homo sapiens N-(3-chloro-4-methylphenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00032
-
 pH and temperature not specified in the publication Homo sapiens N-(4-bromo-3-methylphenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00045
-
 pH and temperature not specified in the publication Homo sapiens N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00058
-
 pH and temperature not specified in the publication Homo sapiens N-(3-chlorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00062
-
 pH and temperature not specified in the publication Homo sapiens N-(4-fluorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00068
-
 pH and temperature not specified in the publication Homo sapiens N-(4-bromophenyl)-6-methoxy-7-[(4-methylmorpholin-2-yl)methoxy]quinazolin-4-amine
0.00072
-
 pH and temperature not specified in the publication Homo sapiens N-(4-bromophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00073
-
 pH and temperature not specified in the publication Homo sapiens N-(3-bromophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00075
-
 pH and temperature not specified in the publication Homo sapiens N-(3-bromophenyl)-6-methoxy-7-[(4-methylmorpholin-2-yl)methoxy]quinazolin-4-amine
0.00096
-
 pH and temperature not specified in the publication Homo sapiens N-(3,5-dichlorophenyl)-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine
0.00119
-
 pH and temperature not specified in the publication Homo sapiens tert-butyl 2-([[4-(3-chloroanilino)-6-methoxyquinazolin-7-yl]oxy]methyl)morpholine-4-carboxylate
0.00147
-
 pH and temperature not specified in the publication Homo sapiens N-(3-chlorophenyl)-6-methoxy-7-[(4-methylmorpholin-2-yl)methoxy]quinazolin-4-amine
0.00231
-
 pH and temperature not specified in the publication Homo sapiens tert-butyl 2-([[4-(4-bromoanilino)-6-methoxyquinazolin-7-yl]oxy]methyl)morpholine-4-carboxylate
0.0025
-
 pH and temperature not specified in the publication Homo sapiens tert-butyl 2-([[4-(3-bromoanilino)-6-methoxyquinazolin-7-yl]oxy]methyl)morpholine-4-carboxylate
0.00321
-
 pH and temperature not specified in the publication Homo sapiens N-[4-fluoro-3-(trifluoromethyl)phenyl]-6-methoxy-7-[(morpholin-2-yl)methoxy]quinazolin-4-amine