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Literature summary for 2.7.10.1 extracted from

  • Krejci, P.; Aklian, A.; Kaucka, M.; Sevcikova, E.; Prochazkova, J.; Masek, J.K.; Mikolka, P.; Pospisilova, T.; Spoustova, T.; Weis, M.; Paznekas, W.A.; Wolf, J.H.; Gutkind, J.S.; Wilcox, W.R.; Kozubik, A.; Jabs, E.W.; Bryja, V.; Salazar, L.; Vesela, I.; Balek, L.
    Receptor tyrosine kinases activate canonical WNT/?-catenin signaling via MAP kinase/LRP6 pathway and direct beta-catenin phosphorylation (2012), PLoS ONE, 7, e35826.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [beta-catenin]-Tyr142 Homo sapiens isoforms FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which increases cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes ADP + [beta-catenin]-Tyr142 phosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [beta-catenin]-Tyr142 isoforms FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which increases cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes Homo sapiens ADP + [beta-catenin]-Tyr142 phosphate
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 ?

General Information

General Information Comment Organism
physiological function potent activation of WNT/beta-catenin signaling by isoforms FGFR2, FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/AKT pathway. Instead, this phenotype depends on ERK MAP kinase-mediated phosphorylation of WNT co-receptor LRP6 at Ser1490 and Thr1572 during its Golgi network-based maturation process. This phosphorylation dramatically increases the cellular response to WNT. FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which is known to increase cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes Homo sapiens