Crystallization (Comment) | Organism |
---|---|
molecular docking studies using inhibitor N4-(3-bromophenyl)-7-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine. The compound binds to the ATP binding site of platelet derived growth factor receptor-beta with the pyrrolo[2,3-d]pyrimidine portion occupying the adenine binding site | Homo sapiens |
molecular docking studies using inhibitor N4-(3-bromophenyl)-7-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine. The pyrrolo[2,3-d]pyrimidine ring occupies the adenine binding portion of the ATP binding site. The 2-NH2 moiety is involved in a hydrogen bond with Glu915 in the Hinge region while the N3 and 4-anilino NH are involved in hydrogen bonds with the backbone of Cys917 in the Hinge region. | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N4-(3-bromo-phenyl)-7-(3,4,5-trimethoxy-benzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | dual inhibitor of platelet derived growth factor recptor-beta and vascular endothelial growth factor receptor 2; dual inhibitor of platelet derived growth factor recptor-beta and vascular endothelial growth factor receptor 2 | Homo sapiens | |
N4-(3-bromophenyl)-7-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Homo sapiens | |
N4-(3-bromophenyl)-7-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | dual inhibitor of platelet derived growth factor recptor-beta and vascular endothelial growth factor receptor 2. In a COLO-205, in vivo tumor mouse model, compound demonstrates inhibition of tumor growth, metastasis, and tumor angiogenesis; dual inhibitor of platelet derived growth factor recptor-beta and vascular endothelial growth factor receptor 2. In a COLO-205, in vivo tumor mouse model, compound demonstrates inhibition of tumor growth, metastasis, and tumor angiogenesis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09619 | - |
- |
Homo sapiens | P35968 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | - |
Homo sapiens | - |
OVCAR-8 cell | - |
Homo sapiens | - |
SF-539 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PDGFRB | - |
Homo sapiens |
PDGFRbeta | - |
Homo sapiens |
platelet derived growth factor receptor-beta | - |
Homo sapiens |
vascular endothelial growth factor receptor 2 | - |
Homo sapiens |
VEGFR-2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0015 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(3-bromophenyl)-7-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0018 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(3-bromo-phenyl)-7-(3,4,5-trimethoxy-benzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0149 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(3-bromophenyl)-7-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0179 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(3-bromophenyl)-7-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0257 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(3-bromo-phenyl)-7-(3,4,5-trimethoxy-benzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.129 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(3-bromophenyl)-7-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine |