Cloned (Comment) | Organism |
---|---|
expression in HEK 293 and B104-1-1 cells | Rattus norvegicus |
expression in HEK 293 and B104-1-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A391E | germ-line mutation in Crouzon syndrome with acanthosis nigricans. The transmembrane domains are able to dimerize, and mutation A391E increases the cross-linking propensities of the two domains | Homo sapiens |
additional information | expression of the isolated transmembrane domain in HEK 293 and B104-1-1 cells and localization to the cell membrane. The transmembrane domains are able to dimerize, and mutation A391E increases the cross-linking propensities of the two domains | Homo sapiens |
additional information | expression of the isolated transmembrane domain in HEK 293 and B104-1-1 cells and localization to the cell membrane. The transmembrane domains are able to dimerize, and mutation V664E increases the cross-linking propensities of the two domains. The transmembrane domain of mutant V664E specifically inhibits the phosphorylation of full-length mutant V664E, while the wild-type transmembrane domain does not. Mutant V664E transmembrane domain does not affect the phosphorylation levels of human full-length tyrosine kinase receptor FGFR3 mutant A391E | Rattus norvegicus |
V664E | oncogenic mutation in TM domain, mutation increases the dimerizing propensities of the transmembrane domains | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22607 | - |
- |
Rattus norvegicus | P06494 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the transmembrane domain of mutant V664E specifically inhibits the phosphorylation of full-length mutant V664E, while the wild-type transmembrane domain does not. Mutant V664E transmembrane domain does not affect the phosphorylation levels of human full-length tyrosine kinase receptor FGFR3 mutant A391E | Rattus norvegicus |
phosphoprotein | the transmembrane domain of mutant V664E specifically inhibits the phosphorylation of full-length mutant V664E, while the wild-type transmembrane domain does not. Mutant V664E transmembrane domain does not affect the phosphorylation levels of human full-length tyrosine kinase receptor FGFR3 mutant A391E | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ErbB2 | - |
Rattus norvegicus |
FGFR3 | - |
Homo sapiens |
fibroblast growth factor receptor 3 | - |
Homo sapiens |
Neu | - |
Rattus norvegicus |
receptor tyrosine-protein kinase erbB-2 | - |
Rattus norvegicus |