Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.1 extracted from

  • Bukowski, R.M.; Yasothan, U.; Kirkpatrick, P.
    Pazopanib (2010), Nat. Rev. Drug Discov., 9, 17-18.
    View publication on PubMed
Search for more literature for 2.7.10.1

Inhibitors

Inhibitors Comment Organism Structure
pazopanib i.e. 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulphonamide, potent inhibitor of vascular endothelial growth factor receotors 1, 2, and 3, platelet-derived growth factor receptor alpha, platelet-derived growth factor receptor beta, and KIT Homo sapiens
sorafenib
-
 Homo sapiens
sunitinib
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
KIT
-
 Homo sapiens
PDGFR-alpha isoform Homo sapiens
PDGFR-beta isoform Homo sapiens
platelet-derived growth factor receptor
-
 Homo sapiens
vascular endothelial growth factor
-
 Homo sapiens
VEGFR1 isoform Homo sapiens
VEGFR2 isoform Homo sapiens
VEGFR3 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens