Literature summary for 2.7.10.1 extracted from

Alberobello, A.T.; DEsposito, V.; Marasco, D.; Doti, N.; Ruvo, M.; Bianco, R.; Tortora, G.; Esposito, I.; Fiory, F.; Miele, C.; Beguinot, F.; Formisano, P.
Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death (2010), J. Biol. Chem., 285, 6563-6572.

Search for more literature for 2.7.10.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	insulin-like growth factor-1 treatment enhances phosphoinositide-dependent kinase-1 interaction with insulin-like growth factor-1 receptor in intact MCF-7 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	loading of fluoresceinated-C43 (fluorescein isothiocyanate (FITC)-C43) into MCF-7 cells significantly reduces insulin-like growth factor-1 receptor/phosphoinositide-dependent kinase-1 interaction	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + phosphoinositide-dependent kinase-1-L-tyrosine	insulin-like growth factor-1 receptor directly interacts with and activates phosphoinositide-dependent kinase-1	Homo sapiens	ADP + phosphoinositide-dependent kinase-1-L-tyrosine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
IGF-1 receptor	-	Homo sapiens
IGF-1R	-	Homo sapiens
Insulin-like growth factor-1 receptor	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)