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Literature summary for 2.7.10.1 extracted from

  • Krishnamoorthy, S.
    Receptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks (2008), PLoS ONE, 3, e2877.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine tyrosine phosphorylation events mediated by aberrant activation of RTK pathways are proven to be involved in the development of several diseases including cancer. 70% of tyrosine phosphorylation events are conserved in human orthologs and paralogs Homo sapiens
additional information around 38% tyrosine phosphorylation events from Drosophila RTK proteins conserved on 185 human proteins are confirmed in vivo tyrosine phosphorylation events Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
Drosophila S2 cells stably transfected with human ErbB1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster P09208
-
-
Homo sapiens P35916
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-

Source Tissue

Source Tissue Comment Organism Textmining
S2 cell
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Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ErbB1 receptor shows three phosphorylation sites (Y1110, Y1172 and Y1192) Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
EGF receptor
-
Homo sapiens
EGF RTK
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Homo sapiens
ERBB1
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Homo sapiens
InR
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Drosophila melanogaster
insulin RTK
-
Drosophila melanogaster
insulin-like receptor
-
Drosophila melanogaster
receptor tyrosine kinase
-
Drosophila melanogaster
receptor tyrosine kinase
-
Homo sapiens
RTK
-
Drosophila melanogaster
RTK
-
Homo sapiens