Literature summary for 2.7.10.1 extracted from

Toth, J.; Egervari, K.; Klekner, A.; Bognar, L.; Szanto, J.; Nemes, Z.; Szollosi, Z.
Analysis of EGFR gene amplification, protein over-expression and tyrosine kinase domain mutation in recurrent glioblastoma (2009), Pathol. Oncol. Res., 15, 225-229.

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Application

Application	Comment	Organism
medicine	EGFR protein is overexpressed in 65% of cases recurrent glioblastoma multiformes. EGFR protein overexpression is associated with EGFR gene amplification in 35% of cases, and with high polysomy in 15% of cases. Mutations in the kinase domain are absent in recurrent glioblastoma multiforme, and this may be a preponderant factor in the lack of major clinical responses of tyrosine kinase inhibitors in glioblastoma multiforme. Responsiveness to EGFR kinase inhibitors is strongly associated with coexpression of EGFRvIII and PTEN	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
EGFR kinase	-	Homo sapiens
EGFR tyrosine kinase	-	Homo sapiens

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Release 2023.1 (January 2023)