Literature summary for 2.7.10.1 extracted from

Takagi, K.; Okuda-Ashitaka, E.; Mabuchi, T.; Katano, T.; Ohnishi, T.; Matsumura, S.; Ohnaka, M.; Kaneko, S.; Abe, T.; Hirata, T.; Fujiwara, S.; Minami, T.; Ito, S.
Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation (2008), Neuroscience, 153, 1278-1288.

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Activating Compound

Activating Compound	Comment	Organism	Structure
capsaicin	c-kit receptor expression is significantly up-regulated in medium-sized dorsal root ganglia neurons after neonatal capsaicin treatment	Mus musculus

Application

Application	Comment	Organism
medicine	c-kit receptor is mainly expressed in peptidergic small-sized dorsal root ganglia neurons and may be involved in pain regulation both peripherally and centrally	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	selective elimination of unmyelinated C-fibers by neonatal capsaicin treatment results in marked reduction of the c-kit receptor and calcitonin gene-related peptide expression in the superficial layer of the spinal cord. C-kit receptor expression is significantly down-regulated in medium-sized dorsal root ganglia neurons after nerve injury	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	male ddY mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	expressed in small- and medium sized dorsal root ganglia neurons, c-kit receptor is co-expressed in 58.4% of calcitonin gene-related peptide-positive, but only 5.1% of isolectin B4-positive, dorsal root ganglia neurons	Mus musculus	-
spinal cord	in the superficial layer of the dorsal horn and co-localized with calcitonin gene-related peptide in central terminals of peptidergic small-sized dorsal root ganglia neurons	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
c-kit receptor	-	Mus musculus
c-Kit receptor tyrosine kinase	-	Mus musculus

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Release 2023.1 (January 2023)