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Literature summary for 2.7.10.1 extracted from

  • Romanelli, R.J.; Wood, T.L.
    Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses (2008), J. Neurochem., 105, 2055-2068.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
clathrin EGFR is internalized classicaly through clathrin-dependent endocytosis Homo sapiens
Epidermal growth factor high-doses stimulate ubiquitination and endocytosis of EGFR through caveolae in HeLa cells Homo sapiens

Application

Application Comment Organism
medicine internatlization and retrograde trafficking of TrkA is required for neuronal survial Rattus norvegicus
medicine RTKs mediate diverse processes within the developing and adult brain. Trafficking of RTKs is required for the specificity and fidelity of signal transduction and consequent biological responses within neural cells. Segregation of signaling complexes and the appropriate delivery of RTKs to these complexes is highly regulated through mechanisms including receptor-sorting sequences, adaptor proteins, specific ligand-receptor interactions, and lipid raft microdomains Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutant insulin receptor, has increased binding to insulin in an acidic endosomal environment in a patient with severe insulin resistant diabetes. Receptor mutant is degraded rather than recycled to the plasma membrane Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Antibody monoclonal antibodies for inhibition of IGF-IR alter receptor trafficking by high affinity binding, promoting receptor degradation and consequently preventing human tumor growth in vivo Homo sapiens
additional information blocking internalization of the IGF-IR results in an attenuation of ERK activation, with no affect on the activation of the PI-3K/Akt pathway Cricetulus griseus
additional information blocking internalization of the EGFR expressed in HeLa cells decreases ERK activity but also increases protein kinase C activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface nerve growth factor-mediated survival in PC12 cells is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway Rattus norvegicus 9986
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endosome PDGFR-beta activates various signaling pathways within endosomes including PI-3K/Akt in human hepatocellular carcinoma cell line Homo sapiens 5768
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additional information caveolae Homo sapiens
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plasma membrane eceptors are internalized within membrane ruffles independent of clathrin (macroendocytosis) Rattus norvegicus 5886
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plasma membrane ErbB4 localizes to lipid rafts in a ligand-dependent manner in HEK-293 cells Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
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Homo sapiens
-
-
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Rattus norvegicus P35739
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-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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Homo sapiens
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HeLa cell
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Homo sapiens
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additional information hepatocellular carcinoma cell line Homo sapiens
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neuron
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Homo sapiens
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oligodendrocyte
-
Homo sapiens
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ovary
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Cricetulus griseus
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PC-12 cell nerve growth factor-mediated survival is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
Egfr
-
Homo sapiens
epidermal growth factor receptor
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Homo sapiens
ERBB1
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Homo sapiens
ErbB4
-
Homo sapiens
FGFR1
-
Homo sapiens
FGFR3
-
Homo sapiens
fibroblast growth factor receptor
-
Homo sapiens
IGF-IR
-
Cricetulus griseus
IGF-IR
-
Homo sapiens
insulin-like growth factor type I receptor
-
Cricetulus griseus
insulin-like growth factor type I receptor
-
Homo sapiens
neurotrophin tyrosine receptor kinase
-
Homo sapiens
neurotrophin tyrosine receptor kinase
-
Rattus norvegicus
p75 neurotrophin receptor
-
Homo sapiens
p75NTR
-
Homo sapiens
PDGFR-alpha
-
Homo sapiens
PDGFR-beta
-
Homo sapiens
platelet-derived growth factor receptor
-
Homo sapiens
receptor tyrosine kinase
-
Cricetulus griseus
receptor tyrosine kinase
-
Homo sapiens
receptor tyrosine kinase
-
Rattus norvegicus
RTK
-
Cricetulus griseus
RTK
-
Homo sapiens
RTK
-
Rattus norvegicus
TrkA
-
Homo sapiens
TrkA
-
Rattus norvegicus
trkB
-
Homo sapiens
TrkC
-
Homo sapiens