Application | Comment | Organism |
---|---|---|
drug development | N-alkyl and N-unsubstituted naphthamides are potent and selective inhibitors of KDR | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(5-((2-methoxyethyl)carbamoyl)naphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide | - |
Homo sapiens | |
4-(5-(cyclopropylcarbamoyl)naphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide | - |
Homo sapiens | |
4-(5-carbamoylnaphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinazolin-4-yloxy)-N-(2-methoxyethyl)-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide methanesulfonate | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(1-methylcyclopropyl)-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2,2,2-trifluoroethyl)-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2-methoxyethyl)-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(3-methoxypropyl)-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-ethyl-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-isopropyl-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-methyl-1-naphthamide | - |
Homo sapiens | |
6-(6,7-dimethoxyquinolin-4-yloxy)-N-propyl-1-naphthamide | - |
Homo sapiens | |
6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-(cyclopropylmethyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-cyclobutyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-cyclopentyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-cyclopropyl-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-cyclopropyl-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens | |
N-tert-butyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35968 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
KDR | - |
Homo sapiens |
vascular endothelial growth factor receptor | - |
Homo sapiens |
VEGFR-2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000037 | - |
- |
Homo sapiens | 4-(5-(cyclopropylcarbamoyl)naphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide | |
0.00000045 | - |
- |
Homo sapiens | N-cyclopropyl-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | |
0.0000006 | - |
- |
Homo sapiens | N-cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | |
0.0000009 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide methanesulfonate | |
0.0000012 | - |
- |
Homo sapiens | 6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | |
0.0000013 | - |
- |
Homo sapiens | N-cyclobutyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | |
0.0000013 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-propyl-1-naphthamide | |
0.0000013 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-ethyl-1-naphthamide | |
0.0000013 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide | |
0.0000013 | - |
- |
Homo sapiens | 4-(5-carbamoylnaphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide | |
0.0000029 | - |
- |
Homo sapiens | N-cyclopropyl-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide | |
0.0000038 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-methyl-1-naphthamide | |
0.0000038 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2,2,2-trifluoroethyl)-1-naphthamide | |
0.0000042 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-(3-methoxypropyl)-1-naphthamide | |
0.0000059 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-isopropyl-1-naphthamide | |
0.000011 | - |
- |
Homo sapiens | N-(cyclopropylmethyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | |
0.000012 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2-methoxyethyl)-1-naphthamide | |
0.000015 | - |
- |
Homo sapiens | N-cyclopentyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide | |
0.000015 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinolin-4-yloxy)-N-(1-methylcyclopropyl)-1-naphthamide | |
0.000022 | - |
- |
Homo sapiens | 4-(5-((2-methoxyethyl)carbamoyl)naphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide | |
0.000028 | - |
- |
Homo sapiens | N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | |
0.000314 | - |
- |
Homo sapiens | 6-(6,7-dimethoxyquinazolin-4-yloxy)-N-(2-methoxyethyl)-1-naphthamide | |
0.0015 | - |
- |
Homo sapiens | N-tert-butyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide |