Literature summary for 2.7.10.1 extracted from

Wilson, C.B.; Ray, M.; Lutz, M.; Sharda, D.; Xu, J.; Hankey, P.A.
The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity (2008), J. Immunol., 181, 2303-2310.

Search for more literature for 2.7.10.1

Activating Compound

Activating Compound	Comment	Organism	Structure
macrophage-stimulating protein	the ligand for RON, inhibits IFN-gamma-induced STAT1 phosphorylation and CIITA expression, resulting in reduced surface levels of MHC class II	Mus musculus

Application

Application	Comment	Organism
medicine	RON receptor regulates both the production of and response to IFN-gamma, resulting in enhanced susceptibility to endotoxin challenge	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	RON(-/-) mice harbor significantly increased systemic levels of IFN-gamma and IL-12p70 and increased levels of IL-12p40 transcript in their spleen. Enhanced susceptibility of RON(-/-) mice to endotoxin challenge is dependent on IFN-gamma-mediated signals	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q62190	CD-1 mice, BALB/cJ mice and C57BL/6 mice	-

Synonyms

Synonyms	Comment	Organism
RON receptor	-	Mus musculus
RON receptor tyrosine kinase	-	Mus musculus

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Release 2023.1 (January 2023)