Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | local environment and membrane surface potential can modulate dimerization and activation of the receptor | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | possible physiological role of the EphA1 receptor as an extracellular pH sensor. Glu547 may serve as a sensor of the environment surrounding the EphA1 receptor on the cell surface, and its deprotonation may partly disrupt the coupling between the extracellular and cytoplasmic domains of the receptor because of transient local melting of helical structure and thus modulate signal transduction | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
38-residue EphA1 fragment 536573 expressed in Escherichia coli BL21(DE3)pLysS | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
membrane | EphA1 transmembrane segments associate in a right-handed parallel alpha-helical bundle, region (544-569)2, through the N-terminal glycine zipper motif A550X3G554X3G558. Dimerization of the transmembrane fragment of the EphA1 receptor | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration | Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
EphA1 | - |
Homo sapiens |
EphA1 receptor | - |
Homo sapiens |
receptor tyrosine kinase EphA1 | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.3 | 6.3 | under acidic conditions, the N terminus of the transmembrane helix is stabilized by an N-capping box formed by the uncharged carboxyl group of Glu547, whereas its deprotonation results in a rearrangement of hydrogen bonds, fractional unfolding of the helix, and a realignment of the helix-helix packing with appearance of additional minor dimer conformation utilizing seemingly the C-terminal GG4-like dimerization motif A560X3G564 | Homo sapiens |