Literature summary for 2.7.10.1 extracted from

Daneshmanesh, A.H.; Mikaelsson, E.; Jeddi-Tehrani, M.; Bayat, A.A.; Ghods, R.; Ostadkarampour, M.; Akhondi, M.; Lagercrantz, S.; Larsson, C.; Osterborg, A.; Shokri, F.; Mellstedt, H.; Rabbani, H.
Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy (2008), Int. J. Cancer, 123, 1190-1195.

Search for more literature for 2.7.10.1

Activating Compound

Activating Compound	Comment	Organism	Structure
PMA/ionomycin	chronic lymphocytic leukemia cells and normal tonsil B cells, which constitutively express Ror1 mRNA, can not be further activated. In contrast, a 15 to 25fold increase in the ROR1 mRNA expression was observed in in vitro activated normal B and T cells	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	no major genomic aberrations (mutations or truncation) of ROR1	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	-	Homo sapiens	9986	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
105000	130000	Western blot analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q01973	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BMMC cell	expresses ROR1 at the mRNA level	Homo sapiens	-
additional information	CLL cell expresses ROR1 mRNA. Blood lymphocytes from chronic lymphocytic leukemia patients express surface Ror1. No difference in the Ror1 protein expression comparing progressive and nonprogressive chronic lymphocytic leukemia patients. ROR1 is not expressed in healthy donor PBMC, isolated normal B cells and T cells or enriched blood granulocytes	Homo sapiens	-
PBMC cell	PBMC cells of chronic lymphocytic leukemia patients express ROR1 at the mRNA level	Homo sapiens	-
tonsil	ROR1 is weakly expressed in tonsil B-cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ROR1	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)