Literature summary for 2.7.10.1 extracted from

Baskar, S.; Kwong, K.Y.; Hofer, T.; Levy, J.M.; Kennedy, M.G.; Lee, E.; Staudt, L.M.; Wilson, W.H.; Wiestner, A.; Rader, C.
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia (2008), Clin. Cancer Res., 14, 396-404.

Search for more literature for 2.7.10.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	EBV transformation does not induce ROR1 protein or ROR1 mRNA expression	Homo sapiens

Application

Application	Comment	Organism
drug development	the restricted, uniform, and constitutive cell surface expression of ROR1 protein in B-CLL provides a strong incentive for the development of targeted therapeutics such as monoclonal antibodies	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells or COS cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
T518M	ROR1 T518M polymorphism does not associate with prognostically distinct B-CLL subtypes	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	cell surface expression of ROR1 is uniform and constitutive, i.e., independent of anatomic niches, independent of biological and clinical heterogeneity of B-CLL, independent of B-cell activation, and at similar levels in all B-CLL samples tested	Homo sapiens	9986	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
120000	-	Western blot analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q01973	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	ROR1 protein is selectively expressed on the surface of B-CLL cells	Homo sapiens	-
additional information	ROR1 protein is selectively expressed on the surface of B-CLL cells of lymphe nodes. Normal B cells, other normal blood cells, and normal adult tissues do not express cell surface ROR1	Homo sapiens	-
peripheral blood	ROR1 protein is selectively expressed on the surface of B-CLL cells	Homo sapiens	-
serum	soluble ROR1 protein is detectable in sera of less than 25% of B-CLL patients and a similar fraction of healthy donors at concentrations below 200 ng/mL	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
receptor tyrosine kinase ROR1	-	Homo sapiens
ROR1	-	Homo sapiens

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Release 2023.1 (January 2023)