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Literature summary for 2.7.10.1 extracted from

  • Boulay, A.; Breuleux, M.; Stephan, C.; Fux, C.; Brisken, C.; Fiche, M.; Wartmann, M.; Stumm, M.; Lane, H.A.; Hynes, N.E.
    The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer (2008), Cancer Res., 68, 3743-3751.
    View publication on PubMed
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
estrogen induces Ret expression Homo sapiens
glial-derived neutrophic factor triggers signaling pathway activation in breast tumor cell lines in a Ret-dependent manner. 10 ng/mL glial-derived neutrophic factor alone or in combination with 100ng/mL glial-derived neutrophic factor receptor alpha1 is the optimal concentration promoting activation of downstream signaling in breast cancer cell lines Homo sapiens

Application

Application Comment Organism
medicine Ret is expressed in primary breast tumors and is functional in a panel of breast tumor cell lines, in particular, cell lines characterized for their dependence on endocrine signaling. Ret signaling stimulates anchorage-independent proliferation of breast cancer cells. Functional interaction with estrogen receptor alpha signaling in vitro strengthens the potential of Ret pathway inhibition in a combination approach with endocrine therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
Ret9-MEN2A overexpressed in NIH-3T3 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
NVP-BBT594
-
 Homo sapiens
siRNA
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BT-474 cell moderate expression Homo sapiens
-
MCF-7 cell high expression Homo sapiens
-
MDA-MB-361 cell high expression Homo sapiens
-
MDA-MB-453 cell moderate expression Homo sapiens
-
additional information high expression in MDA-MB-134 cell, MDA-MB-175 cell, HCC-1419 cell and HCC-2218 cell. no expression in HCC1937 cell, HCC1954 cell, MDA-MB231 cell and MDA-MB468 cell Homo sapiens
-
SK-BR-3 cell moderate expression Homo sapiens
-
T-47D cell moderate expression Homo sapiens
-

Synonyms

Synonyms Comment Organism
Ret receptor tyrosine kinase
-
 Homo sapiens
Ret51
-
 Homo sapiens
Ret9
-
 Homo sapiens