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Literature summary for 2.7.10.1 extracted from

  • Haga, Y.; Hatanaka, K.; Hakomori, S.I.
    Effect of lipid mimetics of GM3 and lyso-GM3 dimer on EGF receptor tyrosine kinase and EGF-induced signal transduction (2008), Biochim. Biophys. Acta, 1780, 393-404.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
Epidermal growth factor EGFR dimer is formed by activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GM3 inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR Homo sapiens
lipid mimetic of GM3 inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR Homo sapiens
lipid mimetic of lyso-GM3 dimer inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR Homo sapiens
lyso-GM3 dimer inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR. A lipid mimetic of lyso-GM3 dimer shows similar strong inhibitory effect on EGF-induced EGFR tyrosine kinase activity, and similar low cytotoxicity, as the authentic lyso-GM3 dimer. Inhibits more strongly than GM3 or a lipid mimetic of GM3 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170000
-
 2 * 170000 Homo sapiens
340000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
dimer 2 * 170000 Homo sapiens

Synonyms

Synonyms Comment Organism
EGF receptor tyrosine kinase
-
 Homo sapiens
Egfr
-
 Homo sapiens
epidermal growth factor receptor
-
 Homo sapiens