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Literature summary for 2.7.10.1 extracted from

  • Edling, C.E.; Hallberg, B.
    c-Kit - A hematopoietic cell essential receptor tyrosine kinase (2007), Int. J. Biochem. Cell Biol., 39, 1995-1998.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
imatinib mesylate potent inhibitor Homo sapiens
phosphotyrosyl phosphatase Shp1 Shp1 binds to c-Kit at Y570 and acts by dephosphorylating the receptor directly, or inhibits c-Kit signalling indirectly by dephosphorylating other receptor-associated protein-tyrosine kinases Homo sapiens
Protein kinase C subsequently phosphorylates c-Kit on specific serine residues leading to negative regulation of c-Kit activation Homo sapiens
STI571 commercial Gleevec/Glivec, specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic stem cell
-
Homo sapiens
-
mast cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
c-kit
-
Homo sapiens
c-Kit RTK
-
Homo sapiens
CD117
-
Homo sapiens
stem cell factor receptor
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens