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Literature summary for 2.7.10.1 extracted from

  • Wang, H.; Kruszewski, A.; Brautigan, D.L.
    Cellular chromium enhances activation of insulin receptor kinase (2005), Biochemistry, 44, 8167-8175.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Insulin activates enzyme tyrosine autophosphorylation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of insulin receptor kinase in CHO cells as GST-fusion protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cr3+ activates insulin receptor tyrosine phosphorylation in vivo Homo sapiens
Mg2+
-
Homo sapiens
Mn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein tyrosine autophosphorylation of the insulin receptor kinase induced by insulin binding, also in vivo tyrosine autophosphorylation in recombinant CHO cells after addition of insulin, dephosphorylation by protein tyrosine phosphatase PTP1B Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + KKHTDDGYMPMSPGVA commercial peptide substrate Homo sapiens ADP + KKHTDDGY-phosphate-MPMSPGVA
-
?
ATP + KKSRGDYMTMQIG commercial peptide substrate Homo sapiens ADP + KKSRGDY-phosphate-MTMQIG
-
?
additional information the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
insulin receptor kinase
-
Homo sapiens
IR kinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens