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Literature summary for 2.7.10.1 extracted from
- Signaling by Kit protein-tyrosine kinase - the stem cell factor receptor (2005), Biochem. Biophys. Res. Commun., 337, 1-13.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| stem cell factor | soluble and membrane-bound glycoprotein, activating ligand of the stem cell receptor i.e. the Kit protein-tyrosine kinase | Mus musculus | |
| stem cell factor | soluble and membrane-bound glycoprotein, activating ligand of the stem cell receptor i.e. the Kit protein-tyrosine kinase, stem cell factor ligand binding induces receptor dimerization and tyrosine kinase activation | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HEK293 cells, co-expression with different proteins interacting with the Kit receptor | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | gain-of-function mutations of Kit receptor are associated with several neoplasms including acute myelogenous leukemia, gastrointestinal stromal tumors, and mastocytomas | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | proto-oncogene Cbl binds to Kit and is activated by parallel binding of adaptor protein APS leading to inactivation and degradation of the Kit receptor | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | Mus musculus | stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility | ADP + a [protein]-L-tyrosine phosphate | - |
? |  |
| ATP + a [protein]-L-tyrosine | Homo sapiens | stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
| additional information | Homo sapiens | the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | tyrosine autophosphorylation of the Kit receptor activated by stem cell factor ligand binding and subsequent dimerization, tyrosine phosphorylation at Tyr568, Tyr570, Tyr703, Tyr721, Tyr730, Tyr900, and Tyr936, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| embryo | - |
Homo sapiens | - |
| embryonic stem cell | - |
Mus musculus | - |
| embryonic stem cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | - |
Mus musculus | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
| ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
| ATP + a [protein]-L-tyrosine | stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility | Mus musculus | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
| ATP + a [protein]-L-tyrosine | stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase | Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
| additional information | the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | activated Kit receptor | Homo sapiens |
| More | the Kit receptor consists of an extracellular domain, a transmembrane segment, a juxtamembrane segment, and a protein kinase domain with an insert of about 80 amino acid residues, stem cell factor ligand binding induces receptor dimerization and tyrosine kinase activation | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Kit protein-tyrosine kinase | - |
Mus musculus |
| Kit protein-tyrosine kinase | - |
Homo sapiens |
| More | Kit receptor is a type III protein-tyrosine kinase | Homo sapiens |
| stem cell receptor | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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