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Literature summary for 2.7.10.1 extracted from

  • Droge, W.
    Oxidative enhancement of insulin receptor signaling: experimental findings and clinical implications (2005), Antioxid. Redox Signal., 7, 1071-1077.
    View publication on PubMed
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
hydrogen peroxide limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin, acts by direct oxidation of the receptor tyrosine kinase or indirectly by oxidation of protein tyrosine phosphatase Homo sapiens
Insulin induces receptor activation by autophosphorylation Homo sapiens
thiol/disulfide regulation of insulin receptor tyrosine kinase activity by shifts in the redox status Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hydrogen peroxide limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
hydrogen peroxide insulin-induced ROS production, limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activation by autophosphorylation of insulin receptor via its tyrosine kinase activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
insulin receptor kinase
-
 Homo sapiens
insulin receptor tyrosine kinase
-
 Homo sapiens
IRK
-
 Homo sapiens