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Literature summary for 2.7.10.1 extracted from
- Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2 (1999), Diabetes, 48, 1237-1244.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| a chimeric receptor consisting of the extracellular domain of insulin receptor and the intracellular domain of IRR is expressed in Chinese hamster ovary cells | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | receptor may play a role in the regulation of beta-cell mass | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9wtl4 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic islet | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein tyrosine | IRS-1 and IRS-2 proteins serve as substrates | Mus musculus | ADP + protein tyrosine phosphate | - |
? | |
| additional information | receptor may play a role in the regulation of beta-cell mass | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| insulin receptor-related protein | - |
Mus musculus |
| IRR-protein tyrosine kinase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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