Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.1 extracted from

  • Flores-Riveros, J.R.; Sibley, E.; Kastelic, T.; Lane, M.D.
    Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit (1989), J. Biol. Chem., 264, 21557-21572.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus P15208
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein insulin stimulates sequential autophosphorylation of Tyr 1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tyrosine insulin stimulates sequential autophosphorylation of Tyr1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation Mus musculus ADP + protein tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
insulin receptor
-
Mus musculus