Protein Variants | Comment | Organism |
---|---|---|
additional information | conversion of Asp-816 to Val in human c-kitR may be an activating mutation and responsible for the constitutive activation of c-kitR in HMC-1 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P10721 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | mast cell leukemia cell line HMC-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol 3-kinase | binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase | Homo sapiens | ADP + phosphorylated phosphatidylinositol 3-kinase | - |
? | |
ATP + protein tyrosine | binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase | Homo sapiens | ADP + protein tyrosine phosphate | - |
? | |
additional information | mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-kitR tyrosine kinase | - |
Homo sapiens |
mast/stem cell growth factor receptor | - |
Homo sapiens |