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Literature summary for 2.7.10.1 extracted from

  • Fernandez, R.; Tabarini, D.; Azpiazu, N.; Frasch, M.; Schlessinger, J.
    The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential (1995), EMBO J., 14, 3373-3384.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
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 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations ?
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster P09208
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification INR proreceptor of 280000 Da is processed proteolytically to generate an insulin-binding alpha subunit of 120000 Da and a beta subunit of 170000 Da with protein tyrosine kinase domain Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations Drosophila melanogaster ?
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 ?

Synonyms

Synonyms Comment Organism
insulin-like receptor
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 Drosophila melanogaster