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Literature summary for 2.7.1.94 extracted from

  • Liu, G.; Ren, X.; Gao, C.; Zhang, W.
    Acylglycerol kinase promotes the proliferation and cell cycle progression of oral squamous cell carcinoma (2015), Mol. Med. Rep., 12, 2225-2230.
    View publication on PubMed
Search for more literature for 2.7.1.94

Protein Variants

Protein Variants Comment Organism
additional information TSCCa cells are transfected with lentiviral vectors encoding short hairpin (sh)RNA targeting human AGK for enzyme AGK knockdown. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q53H12 gene agk
-

Source Tissue

Source Tissue Comment Organism Textmining
oral squamous cell carcinoma cell
-
 Homo sapiens
-
SCC-25 cell
-
 Homo sapiens
-
SCC-9 cell
-
 Homo sapiens
-
Tca-8113 cell
-
 Homo sapiens
-
tongue epithelial cell line
-
 Homo sapiens
-
TSCCa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
AGK
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction cell proliferation and cell cycle progression of an established voral squamous cell carcinoma cell, OSCC, cell line are decreased following enzyme AGK knockdown, and are enhanced by enzyme AGK overexpression in vitro. Aberrant AGK expression in OSCC is associated with cell proliferation and cell cycle progression. Knockdown of AGK results in reduced mRNA and protein expression levels of cyclin D1 and p-Rb, whereas the expres­sion levels of p21 are increased Homo sapiens
physiological function acylglycerol kinase is a multisub­strate lipid kinase, that is associated with the progression of various types of human cancer, it promotes proliferation and cell cycle progression of oral squamous cell carcinoma. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated. The enzyme may promote malignant cancer growth by regulating the expression of cyclin D1 and p21, during the G1-S phase transi­tion Homo sapiens