Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.94 extracted from

  • Spiegel, S.; Milstien, S.
    Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells (2005), Biochem. Soc. Trans., 33, 1362-1365.
    View publication on PubMed
Search for more literature for 2.7.1.94

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme plays a critical role in epidermal growth factor-induced mitogenesis of prostate cancer cells via EGF and IFG-II, and lysophosphatidic acid, the first way can be inhibited by enzyme suppression, the second cannot, enzyme function and regulation in initiation and progression of prostate cancer, lysophosphatidic acid enhances surival and suppresses apoptosis by reducing levels of the apoptosis-promoting protein Bax, and is involved in signal transduction pathways, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell prostate cancer cell line Homo sapiens
-
prostate cancer cell cell lines, high expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-arachidonoyl-glycerol
-
 Homo sapiens ADP + 2-arachidonoyl-glycerol 3-phosphate
-
 ?
ATP + diacylglycerol
-
 Homo sapiens ADP + phosphatidic acid i.e. diacyl-glycerol 3-phosphate ?
ATP + monoacylglycerol
-
 Homo sapiens ADP + lysophosphatidic acid i.e. acyl-sn-glycerol 3-phosphate ?
additional information the enzyme plays a critical role in epidermal growth factor-induced mitogenesis of prostate cancer cells via EGF and IFG-II, and lysophosphatidic acid, the first way can be inhibited by enzyme suppression, the second cannot, enzyme function and regulation in initiation and progression of prostate cancer, lysophosphatidic acid enhances surival and suppresses apoptosis by reducing levels of the apoptosis-promoting protein Bax, and is involved in signal transduction pathways, overview Homo sapiens ?
-
 ?