Literature summary for 2.7.1.91 extracted from

Hammad, S.M.; Crellin, H.G.; Wu, B.X.; Melton, J.; Anelli, V.; Obeid, L.M.
Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages (2008), Prostaglandins Other Lipid Mediat., 85, 107-114.

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Activating Compound

Activating Compound	Comment	Organism	Structure
lipopolysaccharide	increases Sk1 transcription which is accompanied by increased SK activity and generation of sphingosine 1-phosphate. Sphingosine 1-phosphate is able to cause increases in COX-2 and PGE2 levels in RAW cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RAW-264.7 cell	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	knock-down of SK1 using siRNA is able to inhibit the TNF but not the lipopolysaccharide inflammatory response. Knock-down of SK1 enhances both TNF- and lipopolysaccharide-induced apoptosis	Mus musculus

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Release 2023.1 (January 2023)