Literature summary for 2.7.1.91 extracted from

Huwiler, A.; Doell, F.; Ren, S.; Klawitter, S.; Greening, A.; Roemer, I.; Bubnova, S.; Reinsberg, L.; Pfeilschifter, J.
Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism (2006), Biochim. Biophys. Acta, 1761, 367-376.

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Activating Compound

Activating Compound	Comment	Organism	Structure
12-O-tetradecanoylphorbol-13-acetate	50 nM, maximum increase in activity after 24 h	Homo sapiens
histamine	0.001 mM, up to 5fold increase of activity after 20 h	Homo sapiens
additional information	not activated by histamine or 12-O-tetradecanoylphorbol-13-acetate	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
KCl	1 mM	Homo sapiens
additional information	not inhibited by KCl	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
42000	-	SDS-PAGE, splice variant SK-1a	Homo sapiens
51000	-	SDS-PAGE, splice variant SK-1b	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NRA0	-	-
Homo sapiens	Q9NYA1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
EAhy 926 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + sphingosine	-	Homo sapiens	ADP + sphingosine 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
SK-1	-	Homo sapiens
SK-2	-	Homo sapiens
sphinganine kinase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)