Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2',2'-difluorodeoxycytidine | Homo sapiens | i.e. gemcitabine, transport and metabolism in vivo, overview | ADP + 2',2'-difluorodeoxycytidine monophosphate | - |
? | |
ATP + deoxycytidine | Homo sapiens | - |
ADP + dCMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic cancer cell | - |
Homo sapiens | - |
PK-9 cell | - |
Homo sapiens | - |
RPK-9 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2',2'-difluorodeoxycytidine | i.e. gemcitabine | Homo sapiens | ADP + 2',2'-difluorodeoxycytidine monophosphate | - |
? | |
ATP + 2',2'-difluorodeoxycytidine | i.e. gemcitabine, transport and metabolism in vivo, overview | Homo sapiens | ADP + 2',2'-difluorodeoxycytidine monophosphate | - |
? | |
ATP + deoxycytidine | - |
Homo sapiens | ADP + dCMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | deoxxycytidine kinase inhibition causes gemcitabine resistance, overview | Homo sapiens |
metabolism | 2',2'-difluorodeoxycytidine, i.e. gemcitabine, is phosphorylated intracellularly via multiple steps, and the triphosphate inhibits DNA synthesis by interfering with incorporation of endogenous dCTP into DNA, deocycytidine kinase catalyzes the first phosphorylation step, overview | Homo sapiens |