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Literature summary for 2.7.1.74 extracted from

  • Shord, S.; Patel, S.
    Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines (2009), J. Exp. Clin. Cancer Res., 28, 76.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
paclitaxel paclitaxel increases dCK (10% to 50%) activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H460 cell
-
 Homo sapiens
-
NCI-H520 cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2',2'-difluoro-2'-deoxycytidine i.e. gemcitabine Homo sapiens ADP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
 ?
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens paclitaxel significantly decreases dCK mRNA and protein levels in H460 and H520 cells down