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Literature summary for 2.7.1.74 extracted from

  • Kocabas, N.A.; Aksoy, P.; Pelleymounter, L.L.; Moon, I.; Ryu, J.S.; Gilbert, J.A.; Salavaggione, O.E.; Eckloff, B.W.; Wieben, E.D.; Yee, V.; Weinshilboum, R.M.; Ames, M.M.
    Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics (2008), Drug Metab. Dispos., 36, 1951-1959.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Cos-1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information sequencing of deoxycytidine kinase and cytidine monophosphate kinase using 240 DNA samples reveals 28 polymorphisms in deoxycytidine kinase. Variant allozyme enzyme activities range from 32% to 105% of the wild type activity with no significant differences in apparent Km values except for a V24/S122 double variant enzyme. Relative levels of immunoreactive protein after expression in COS-1 cells parallel relative levels of enzyme activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0146
-
2',2'-difluorodeoxycytidine wild-type Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27707
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2',2'-difluorodeoxycytidine i.e. gemcitabine Homo sapiens ADP + 2',2'-difluorodeoxycytidine 5'-monophosphate
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