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Literature summary for 2.7.1.74 extracted from

  • Smal, C.; Van Den Neste, E.; Maerevoet, M.; Poire, X.; Theate, I.; Bontemps, F.
    Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukemia lymphocytes (2007), Cancer Lett., 253, 68-73.
    View publication on PubMed
Search for more literature for 2.7.1.74

Activating Compound

Activating Compound Comment Organism Structure
2-chloro-2'-deoxyadenosine increases activity by increasing phosphorylation of Ser74 Homo sapiens
aphidicolin increases activity by increasing phosphorylation of Ser74 Homo sapiens
etoposide increases activity by increasing phosphorylation of Ser74 Homo sapiens
genistein increases activity by increasing phosphorylation of Ser74 Homo sapiens
additional information UV-C irradiation increases activity by increasing phosphorylation of Ser74 Homo sapiens

Application

Application Comment Organism
analysis deoxycytidine kinase from B-cell chronic lymphocytic leukaemia lymphocytes can be detected by use of anti-phospho-ser74 antibodies Homo sapiens
medicine interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK 293T cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ in complex with ATP Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + 2-chloro-2'-deoxyadenosine Homo sapiens phosphorylation of chemotherapeutically important nucleoside analogues NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
NTP + 9-beta-D-arabinosyl-2-fluoroadenine Homo sapiens phosphorylation of chemotherapeutically important nucleoside analogues NDP + 9-beta-D-arabinosyl-2-fluoroadenine 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
 patients with B-cell chronic lymphocytic leukaemia
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein regulation of activity by phosphorylation of Ser-74 Homo sapiens
phosphoprotein interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-CLL cell
-
 Homo sapiens
-
blood
-
 Homo sapiens
-
lymphocyte B-cell chronic lymphocytic leukaemia lymphocyte Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxy-CMP
-
 ?
NTP + 2-chloro-2'-deoxyadenosine phosphorylation of chemotherapeutically important nucleoside analogues Homo sapiens NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
NTP + 9-beta-D-arabinosyl-2-fluoroadenine phosphorylation of chemotherapeutically important nucleoside analogues Homo sapiens NDP + 9-beta-D-arabinosyl-2-fluoroadenine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens