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Literature summary for 2.7.1.74 extracted from

  • Smal, C.; Cardoen, S.; Betrand, L.; Delacauw, A.; Ferrant, A.; Van den Berghe, G.; Van den Neste, E.; Bontemps, F.
    Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells (2003), Biochem. Pharmacol., 69, 95-103.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-chloro-2'-deoxyadenosine
-
Homo sapiens
AG-490
-
Homo sapiens
daidzein
-
Homo sapiens
genistein
-
Homo sapiens
okadaic acid
-
Homo sapiens
PD-98059
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H-7 reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine Homo sapiens
protein phosphatase lambda
-
Homo sapiens
staurosporine reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxyadenosine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis ADP + 2'-deoxyadenosine 5'-phosphate
-
?
ATP + 2'-deoxycytidine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis ADP + 2'-deoxycytidine 5'-phosphate
-
?
additional information Homo sapiens key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy ?
-
?
NTP + 2-chloro-2'-deoxyadenosine Homo sapiens i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
?
NTP + 9-beta-D-arabinosyl 2-fluoroadenine Homo sapiens activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
?
UTP + 2',3'-dideoxycytidine Homo sapiens i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections UDP + 2',3'-dideoxycytidine 5'-phosphate
-
?
UTP + 2'-deoxy-3'-thiacytidine Homo sapiens i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
?
UTP + 2'-deoxyadenosine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis UDP + 2'-deoxyadenosine 5'-phosphate
-
?
UTP + 2'-deoxycytidine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis UDP + 2'-deoxycytidine 5'-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the enzyme involved in the regulation of enzyme activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
CCRF-CEM cell
-
Homo sapiens
-
EHEB cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxyadenosine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens ADP + 2'-deoxyadenosine 5'-phosphate
-
?
ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?
ATP + 2'-deoxycytidine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?
additional information key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy Homo sapiens ?
-
?
NTP + 2-chloro-2'-deoxyadenosine i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies Homo sapiens NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
?
NTP + 9-beta-D-arabinosyl 2-fluoroadenine activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies Homo sapiens NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
?
UTP + 2',3'-dideoxycytidine i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections Homo sapiens UDP + 2',3'-dideoxycytidine 5'-phosphate
-
?
UTP + 2'-deoxy-3'-thiacytidine i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections Homo sapiens UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
?
UTP + 2'-deoxyadenosine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens UDP + 2'-deoxyadenosine 5'-phosphate
-
?
UTP + 2'-deoxycytidine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens UDP + 2'-deoxycytidine 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
dCK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
UTP
-
Homo sapiens