Application | Comment | Organism |
---|---|---|
medicine | enzyme is active and important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genetic organization, located on chromosome 4q13.3-4q21.1, expression as GFP-fusion protein with location in the nucleus | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | native enzyme | Homo sapiens | 5829 | - |
additional information | the enzyme possesses a nuclear import signal sequence | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxyadenosine | Homo sapiens | - |
ADP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
ATP + 2'-deoxycytidine | Homo sapiens | - |
ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
ATP + 2'-deoxyguanosine | Homo sapiens | - |
ADP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
additional information | Homo sapiens | de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview, enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview | ? | - |
? | |
UTP + 2'-deoxyadenosine | Homo sapiens | - |
UDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
UTP + 2'-deoxycytidine | Homo sapiens | - |
UDP + 2'-deoxycytidine 5'-phosphate | - |
? | |
UTP + 2'-deoxyguanosine | Homo sapiens | - |
UDP + 2'-deoxyguanosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27707 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
liver | high enzyme content in fetal liver, very low content in adult liver | Homo sapiens | - |
additional information | enzyme expression throughout the cell cycle, tissue-specific expression | Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxyadenosine | - |
Homo sapiens | ADP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
ATP + 2'-deoxyguanosine | - |
Homo sapiens | ADP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
additional information | de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview, enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview | Homo sapiens | ? | - |
? | |
additional information | enzyme can utilizes several phosphate donors, with preference for UTP | Homo sapiens | ? | - |
? | |
UTP + 1-beta-D-arabinofuranosylcytosine | i.e. cytarabine | Homo sapiens | UDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate | - |
? | |
UTP + 2',2'-difluorodeoxycytidine | i.e. gemcitabine | Homo sapiens | UDP + 2',2'-difluorodeoxycytidine 5'-phosphate | - |
? | |
UTP + 2',3'-dideoxycytidine | - |
Homo sapiens | UDP + 2',3'-dideoxycytidine 5'-phosphate | - |
? | |
UTP + 2'-deoxy-3'-thiacytidine | - |
Homo sapiens | UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate | - |
? | |
UTP + 2'-deoxyadenosine | - |
Homo sapiens | UDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
UTP + 2'-deoxycytidine | - |
Homo sapiens | UDP + 2'-deoxycytidine 5'-phosphate | - |
? | |
UTP + 2'-deoxyguanosine | - |
Homo sapiens | UDP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
UTP + 2-chloro-2'-deoxyadenosine | i.e. cladribine | Homo sapiens | UDP + 2-chloro-2'-deoxyadenosine 5'-phosphate | - |
? | |
UTP + 2-fluoro-9-beta-D-arabinofuranosyladenine | i.e. fludarabine | Homo sapiens | UDP + 2-fluoro-9-beta-D-arabinofuranosyladenine 5'-phosphate | - |
? | |
UTP + 9-beta-D-arabinofuranosylguanine | i.e. nelarabine | Homo sapiens | UDP + 9-beta-D-arabinofuranosylguanine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
UTP | preferred, in vivo important phoaphate donor | Homo sapiens |