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Literature summary for 2.7.1.74 extracted from

  • Van Rompay, A.R.; Johansson, M.; Karlsson, A.
    Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases (2003), Pharmacol. Ther., 100, 119-139.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is active and important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
genetic organization, located on chromosome 4q13.3-4q21.1, expression as GFP-fusion protein with location in the nucleus Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol native enzyme Homo sapiens 5829
-
additional information the enzyme possesses a nuclear import signal sequence Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxyadenosine Homo sapiens
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
?
ATP + 2'-deoxycytidine Homo sapiens
-
ADP + 2'-deoxycytidine 5'-phosphate
-
?
ATP + 2'-deoxyguanosine Homo sapiens
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
?
additional information Homo sapiens de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview, enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview ?
-
?
UTP + 2'-deoxyadenosine Homo sapiens
-
UDP + 2'-deoxyadenosine 5'-phosphate
-
?
UTP + 2'-deoxycytidine Homo sapiens
-
UDP + 2'-deoxycytidine 5'-phosphate
-
?
UTP + 2'-deoxyguanosine Homo sapiens
-
UDP + 2'-deoxyguanosine 5'-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27707
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
Homo sapiens
-
brain
-
Homo sapiens
-
liver high enzyme content in fetal liver, very low content in adult liver Homo sapiens
-
additional information enzyme expression throughout the cell cycle, tissue-specific expression Homo sapiens
-
skeletal muscle
-
Homo sapiens
-
thymus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxyadenosine
-
Homo sapiens ADP + 2'-deoxyadenosine 5'-phosphate
-
?
ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?
ATP + 2'-deoxyguanosine
-
Homo sapiens ADP + 2'-deoxyguanosine 5'-phosphate
-
?
additional information de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview, enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview Homo sapiens ?
-
?
additional information enzyme can utilizes several phosphate donors, with preference for UTP Homo sapiens ?
-
?
UTP + 1-beta-D-arabinofuranosylcytosine i.e. cytarabine Homo sapiens UDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
?
UTP + 2',2'-difluorodeoxycytidine i.e. gemcitabine Homo sapiens UDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
?
UTP + 2',3'-dideoxycytidine
-
Homo sapiens UDP + 2',3'-dideoxycytidine 5'-phosphate
-
?
UTP + 2'-deoxy-3'-thiacytidine
-
Homo sapiens UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
?
UTP + 2'-deoxyadenosine
-
Homo sapiens UDP + 2'-deoxyadenosine 5'-phosphate
-
?
UTP + 2'-deoxycytidine
-
Homo sapiens UDP + 2'-deoxycytidine 5'-phosphate
-
?
UTP + 2'-deoxyguanosine
-
Homo sapiens UDP + 2'-deoxyguanosine 5'-phosphate
-
?
UTP + 2-chloro-2'-deoxyadenosine i.e. cladribine Homo sapiens UDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
?
UTP + 2-fluoro-9-beta-D-arabinofuranosyladenine i.e. fludarabine Homo sapiens UDP + 2-fluoro-9-beta-D-arabinofuranosyladenine 5'-phosphate
-
?
UTP + 9-beta-D-arabinofuranosylguanine i.e. nelarabine Homo sapiens UDP + 9-beta-D-arabinofuranosylguanine 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
dCK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
UTP preferred, in vivo important phoaphate donor Homo sapiens