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Literature summary for 2.7.1.74 extracted from

  • Keszler, G.; Virga, S.; Spasokoukotskaja, T.; Bauer, P.I.; Sasvari-Szekely, M.; Staub, M.
    Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity (2005), Arch. Biochem. Biophys., 436, 69-77.
    View publication on PubMed
Search for more literature for 2.7.1.74

Activating Compound

Activating Compound Comment Organism Structure
2'-deoxyadenosine/deoxycoformycin no stimulation of enzyme activity by either compound if applied alone, with both compound at 0.01 mM 2.4fold activation occurs Homo sapiens
2-chloro-2'-deoxyadenosine 2.4fold activation at 0.003 mM, activation is slightly inhibited by 3-aminobenzamide, the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity Homo sapiens
aphidicolin
-
 Homo sapiens
etoposide
-
 Homo sapiens
additional information enzyme is activated by inhibitors of signal transduction enzymes, overview, deoxycytidine prevents activation of the enzyme, no activation by PD 98059 and SB 203580 in presence of deoxycytidine Homo sapiens
PD 153035 i.e. 4-(3-bromoanilino)-6,7-dimethoxy-quinazinoline Homo sapiens
PD 98059 i.e. 2'-amino-3'-methoxyflavone, in absence of deoxycytidine Homo sapiens
SB 203580 in absence of deoxycytidine Homo sapiens
tyrphostin A47
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sorbitol
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxycytidine Homo sapiens
-
 ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
additional information Homo sapiens the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte tonsillar Homo sapiens
-
tonsil lymphocyte Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + 2-chloro-2'-deoxyadenosine i.e. cladribine Homo sapiens ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
additional information the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity Homo sapiens ?
-
 ?
additional information the enzyme shows broad substrate specificity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens