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Literature summary for 2.7.1.74 extracted from
- Purine nucleoside kinases in human T- and B-lymphoblasts (1983), Biochim. Biophys. Acta, 761, 34-40.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine arabinoside | weak, not with deoxyadenosine as substrate | Homo sapiens |  |
| CTP | strong, ATP as substrate | Homo sapiens | |
| cytidine | weak | Homo sapiens | |
| cytosine arabinoside | ATP as substrate; deoxycytidine as substrate; strong, deoxyadenosine as substrate | Homo sapiens | |
| dATP | strong | Homo sapiens | |
| dCTP | - |
Homo sapiens | |
| deoxyadenosine | - |
Homo sapiens | |
| deoxycytidine | deoxyadenosine as substrate | Homo sapiens | |
| deoxyguanosine | deoxyguanosine as substrate, cytosolic isozyme I, weak | Homo sapiens | |
| dGTP | ATP as substrate | Homo sapiens | |
| dTTP | ATP as substrate; weak | Homo sapiens | |
| GTP | not, deoxyadenosine as substrate; weak, ATP and deoxycytidine as substrate | Homo sapiens | |
| additional information | little or no inhibition by AMP, dTMP, adenosine, guanosine | Homo sapiens | |
| Nucleosides | overview, ATP and deoxyadenosine or deoxycytidine as substrate | Homo sapiens | |
| UTP | ATP as substrate; not with deoxyadenosine as substrate | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0033 | 0.0093 | deoxycytidine | - |
Homo sapiens | |
| 0.15 | - |
deoxyadenosine | pH 8.0 | Homo sapiens | |
| 0.33 | 0.43 | deoxyguanosine | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| viral nucleocapsid | Epstein-Barr-Virus | Homo sapiens | 19013 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BALL-1 cell | - |
Homo sapiens | - |
| CCRF-CEM cell | - |
Homo sapiens | - |
| lymphoblast | T-lymphoblasts, cell lines MOLT 4F, CCRF, CEM and RPMI 8402, B-lymphoblasts cell lines BALL 1 and EBV (Epstein-Barr-virus) transformed B-lymphoblasts | Homo sapiens | - |
| MOLT-4F cell | - |
Homo sapiens | - |
| RPMI-8402 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 5'-dCMP | - |
? | |
| NTP + deoxyadenosine | - |
Homo sapiens | NDP + dAMP | - |
? | |
| NTP + deoxycytidine | - |
Homo sapiens | NDP + dCMP | - |
? | |
| NTP + deoxyguanosine | - |
Homo sapiens | NDP + dGMP | - |
? | |
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Release 2023.1 (January 2023)
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