Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60331 | - |
- |
Homo sapiens | Q99755 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
TZM-bl cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 72000, isoform PIP5K1alpha, SDS-PAGE | Homo sapiens |
? | x * 90000, isoform PIP5K1gamma, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PIP5K1alpha | isoform | Homo sapiens |
PIP5K1gamma | isoform | Homo sapiens |
type I phosphatidylinositol-4-phosphate 5-kinase alpha | - |
Homo sapiens |
type I phosphatidylinositol-4-phosphate 5-kinase gamma | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | downregulation of isoforms PIP5K1alpha and PIP5K1gamma strongly impairs the targeting of HIV-1 Gag polyprotein precursor Pr55Gag to the plasma membrane with a rerouting of the polyprotein within intracellular compartments | Homo sapiens |
physiological function | the 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pools produced by isoforms PIP5K1alpha and gamma are involved in HIV-1 Gag polyprotein precursor Pr55Gag plasma membrane targeting process | Homo sapiens |