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BRENDA support

Literature summary for 2.7.1.68 extracted from

  • Gonzales, B.; de Rocquigny, H.; Beziau, A.; Durand, S.; Burlaud-Gaillard, J.; Lefebvre, A.; Krull, S.; Emond, P.; Brand, D.; Piver, E.
    Type I phosphatidylinositol-4-phosphate 5-kinases alpha and gamma play a key role in targeting HIV-1 Pr55Gag to the plasma membrane (2020), J. Virol., 94, e00189-20 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60331
-
-
Homo sapiens Q99755
-
-

Source Tissue

Source Tissue Comment Organism Textmining
TZM-bl cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Subunits

Subunits Comment Organism
? x * 72000, isoform PIP5K1alpha, SDS-PAGE Homo sapiens
? x * 90000, isoform PIP5K1gamma, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PIP5K1alpha isoform Homo sapiens
PIP5K1gamma isoform Homo sapiens
type I phosphatidylinositol-4-phosphate 5-kinase alpha
-
Homo sapiens
type I phosphatidylinositol-4-phosphate 5-kinase gamma
-
Homo sapiens

General Information

General Information Comment Organism
malfunction downregulation of isoforms PIP5K1alpha and PIP5K1gamma strongly impairs the targeting of HIV-1 Gag polyprotein precursor Pr55Gag to the plasma membrane with a rerouting of the polyprotein within intracellular compartments Homo sapiens
physiological function the 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pools produced by isoforms PIP5K1alpha and gamma are involved in HIV-1 Gag polyprotein precursor Pr55Gag plasma membrane targeting process Homo sapiens