Literature summary for 2.7.1.68 extracted from

Nguyen, T.T.N.; Seo, E.; Choi, J.; Le, O.T.T.; Kim, J.Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid (2017), Cell. Signal., 38, 159-170 .

Search for more literature for 2.7.1.68

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	Mus musculus	-	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BV-2 cell	-	Mus musculus	-
microglia	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	Mus musculus	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol 4-phosphate 5-kinase alpha	isoform	Mus musculus
PIP5Kalpha	isoform	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	treatment of BV-2 microglial cells with lipoteichoic acid increases isoform PIP5Kalpha expression in BV-2 and primary microglial cells, but not in primary cultures from Toll-like receptor 2-deficient mice	up

General Information

General Information	Comment	Organism
malfunction	isoform PIP5Kalpha knockdown of BV-2 cells significantly suppresses lipoteichoic acid-induced activation of toll-like receptor 2 downstream signaling, including the production of proinflammatory cytokines and phosphorylation of nuclear factor-kappaB, JNK, and p38 MAP kinase. Besides, isoform PIP5Kalpha knockdown inhibits phagocytic uptake of Escherichia coli particles and autophagy-related vesicle formation triggered by lipoteichoic acid	Mus musculus
physiological function	phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid	Mus musculus

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Release 2023.1 (January 2023)