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Literature summary for 2.7.1.68 extracted from

  • Thapa, N.; Choi, S.; Hedman, A.; Tan, X.; Anderson, R.A.
    Phosphatidylinositol phosphate 5-kinase Igammai2 in association with Src controls anchorage-independent growth of tumor cells (2013), J. Biol. Chem., 288, 34707-34718.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.68

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCC-1954 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
NIH-3T3 cell
-
 Homo sapiens
-
SUM-1315MO2 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol phosphate 5-kinase Igammai2
-
 Homo sapiens
PIPKIgammaI2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme regulates Src activation downstream of growth factor receptors and integrins. The enzyme and Src synergistically control anchorage-independent tumor cell growth Homo sapiens