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Literature summary for 2.7.1.68 extracted from

  • Lacalle, R.A.; Peregil, R.M.; Albar, J.P.; Merino, E.; Martinez-A, C.; Merida, I.; Manes, S.
    Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement (2007), J. Cell Biol., 179, 1539-1553.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information knockdown of phosphatidylinositol 4-phosphate 5-kinase beta with siRNA inhibits cell polarization and impairs cell directionality during dHL60 chemotaxis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens phosphatidylinositol 4-phosphate 5-kinase beta is involved in polarization at the uropod of neutrophil-differentiated HL60 cells. Phosphatidylinositol 4-phosphate 5-kinase beta localization is independent of its lipid kinase activity, but requires the 83 C-terminal amino acids. The C-terminus interacts with 4.1-ezrin-radixin-moesin-binding phosphoprotein 50, which enables further interactions with ezrin-radixin-moesin proteins and the Rho-GDP dissociation inhibitor ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 isoform phosphatidylinositol 4-phosphate 5-kinase beta, type I enzyme
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphatidylinositol 4-phosphate 5-kinase beta is involved in polarization at the uropod of neutrophil-differentiated HL60 cells. Phosphatidylinositol 4-phosphate 5-kinase beta localization is independent of its lipid kinase activity, but requires the 83 C-terminal amino acids. The C-terminus interacts with 4.1-ezrin-radixin-moesin-binding phosphoprotein 50, which enables further interactions with ezrin-radixin-moesin proteins and the Rho-GDP dissociation inhibitor Homo sapiens ?
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 ?