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Literature summary for 2.7.1.68 extracted from

  • Husebye, E.S.; Flatmark, T.
    Purification and kinetic properties of a soluble phosphatidylinositol-4-phosphate kinase of the bovine adrenal medulla with emphasis on its inhibition by calcium ions (1989), Biochim. Biophys. Acta, 1010, 250-257.
    View publication on PubMed
Search for more literature for 2.7.1.68

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Bos taurus
Ca2+ free Ca2+, IC50: about 0.0001 mM Bos taurus
Trifluoperazine IC50: about 0.015 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.129
-
 ATP pH 7.0, 25°C Bos taurus
0.129
-
 ATP ATP in form of MgATP2- Bos taurus
0.13
-
 ATP pH 7, 25°C, at 5 mM Mg2+ Bos taurus
0.13
-
 ATP ATP in form of MgATP2- Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ stimulates Bos taurus
Mg2+ stimulates Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
 Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5 pH 6.5: about 35% of maximal activity, pH 8.5: about 60% of maximal activity Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
 free Ca2+, IC50: about 0.0001 mM Bos taurus Ca2+
0.015
-
 IC50: about 0.015 mM Bos taurus Trifluoperazine