Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.67 extracted from

  • Kandepedu, N.; Gonzalez Cabrera, D.; Eedubilli, S.; Taylor, D.; Brunschwig, C.; Gibhard, L.; Njoroge, M.; Lawrence, N.; Paquet, T.; Eyermann, C.J.; Spangenberg, T.; Basarab, G.S.; Street, L.J.; Chibale, K.
    Identification, characterization, and optimization of 2,8-disubstituted-1,5-naphthyridines as novel Plasmodium falciparum phosphatidylinositol-4-kinase inhibitors with in vivo efficacy in a humanized mouse model of malaria (2018), J. Med. Chem., 61, 5692-5703 .
    View publication on PubMed
Search for more literature for 2.7.1.67

Inhibitors

Inhibitors Comment Organism Structure
(1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide BRD73842 Plasmodium falciparum
(1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide BRD73842 Plasmodium vivax
(3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
-
 Plasmodium falciparum
(3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
-
 Plasmodium vivax
1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
-
 Plasmodium falciparum
1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
-
 Plasmodium vivax
2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
-
 Plasmodium falciparum
2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
-
 Plasmodium vivax
2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide BQR695 Plasmodium falciparum
2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide BQR695 Plasmodium vivax
3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
-
 Plasmodium falciparum
3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
-
 Plasmodium vivax
3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
-
 Plasmodium falciparum
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
-
 Plasmodium vivax
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
-
 Plasmodium falciparum
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
-
 Plasmodium vivax
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine MMV390048 Plasmodium falciparum
5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine MMV390048 Plasmodium vivax
5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide MMV024101 Plasmodium falciparum
5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide MMV024101 Plasmodium vivax
5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium falciparum
5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium vivax
5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium falciparum
5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium vivax
5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium falciparum
5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium vivax
8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
-
 Plasmodium falciparum
8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
-
 Plasmodium vivax
8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
-
 Plasmodium falciparum
8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
-
 Plasmodium vivax
artesunate
-
 Plasmodium falciparum
artesunate
-
 Plasmodium vivax
BQR695
-
 Plasmodium falciparum
BQR695
-
 Plasmodium vivax
BRD73842
-
 Plasmodium falciparum
BRD73842
-
 Plasmodium vivax
Chloroquine
-
 Plasmodium falciparum
Chloroquine
-
 Plasmodium vivax
KDU691
-
 Plasmodium falciparum
KDU691
-
 Plasmodium vivax
MMV390048
-
 Plasmodium falciparum
MMV390048
-
 Plasmodium vivax
N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium falciparum
N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium vivax
N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide KDU691 Plasmodium falciparum
N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide KDU691 Plasmodium vivax
N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium falciparum
N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium vivax
N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium falciparum
N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium vivax
N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
-
 Plasmodium falciparum
N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
-
 Plasmodium vivax
N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
-
 Plasmodium falciparum
N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
-
 Plasmodium vivax

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Plasmodium falciparum
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol Plasmodium vivax
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
 chloroquine sensitive (NF54) strain
-
Plasmodium falciparum
-
 multidrug resistant (K1) strain
-
Plasmodium vivax
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Plasmodium falciparum ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Plasmodium vivax ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-4-kinase
-
 Plasmodium falciparum
phosphatidylinositol-4-kinase
-
 Plasmodium vivax
PI4K
-
 Plasmodium falciparum
PI4K
-
 Plasmodium vivax

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000015
-
 pH and temperature not specified in the publication Plasmodium vivax N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
0.0000015
-
 pH and temperature not specified in the publication Plasmodium vivax KDU691
0.0000034
-
 pH and temperature not specified in the publication Plasmodium vivax 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine
0.0000034
-
 pH and temperature not specified in the publication Plasmodium vivax MMV390048
0.0000035
-
 pH and temperature not specified in the publication Plasmodium vivax 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
0.0000035
-
 pH and temperature not specified in the publication Plasmodium vivax BQR695
0.000019
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.00002
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000021
-
 pH and temperature not specified in the publication Plasmodium vivax (1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide
0.000021
-
 pH and temperature not specified in the publication Plasmodium vivax BRD73842
0.000022
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000025
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
0.000029
-
 pH and temperature not specified in the publication Plasmodium falciparum 1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
0.000031
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
0.000031
-
 pH and temperature not specified in the publication Plasmodium falciparum N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000046
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
0.000046
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.00005
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000063
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000065
-
 pH and temperature not specified in the publication Plasmodium falciparum N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000084
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
0.000084
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000087
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
0.000091
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000102
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000105
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.00011
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
0.000119
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000122
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000147
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
0.000187
-
 pH and temperature not specified in the publication Plasmodium falciparum (3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
0.000203
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000215
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000238
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000265
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000277
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000284
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
0.000355
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
0.000377
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
0.000412
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000424
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
0.000437
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000457
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000496
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
0.000543
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
0.000708
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000719
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
0.000727
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000728
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000745
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
0.00091
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
0.000935
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum 2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum 8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
0.001015
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.00136
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
0.001432
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
0.001484
-
 pH and temperature not specified in the publication Plasmodium falciparum 8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
0.001755
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
0.002623
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
0.003668
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum 2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum 4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum 4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
0.00618
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide