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Literature summary for 2.7.1.67 extracted from
- Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms (2012), Trends Biochem. Sci., 37, 293-302.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PI4Ks are panviral host therapeutic targets | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Saccharomyces cerevisiae | 5783 | - |
| endosome | - |
Homo sapiens | 5768 | - |
| endosome | - |
Saccharomyces cerevisiae | 5768 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| Golgi apparatus | - |
Saccharomyces cerevisiae | 5794 | - |
| mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
| mitochondrial outer membrane | - |
Saccharomyces cerevisiae | 5741 | - |
| additional information | Rac regulates PI4KIIbeta membrane recruitment | Homo sapiens | - |
- |
| plasma membrane | - |
Homo sapiens | 5886 | - |
| plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
| trans-Golgi network | - |
Homo sapiens | 5802 | - |
| trans-Golgi network | - |
Saccharomyces cerevisiae | 5802 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
| Mg2+ | required | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | Saccharomyces cerevisiae | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| additional information | Saccharomyces cerevisiae | Lsb6p binds Las17p, a homologue of the mammalian Wiscott-Aldrich syndrome protein, and WASP | ? | - |
? | |
| additional information | Homo sapiens | PI4KIIbeta is associated with Hsp90 | additional information | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
genes STT4, PIK1 and LSB6 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| lipoprotein | PI4KIIbeta and PI4KIIalpha are palmitoylated | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Saccharomyces cerevisiae | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| additional information | Lsb6p binds Las17p, a homologue of the mammalian Wiscott-Aldrich syndrome protein, and WASP | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | PI4KIIbeta is associated with Hsp90 | Homo sapiens | additional information | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | domain organization of PI4Ks: Lsb6p with two catalytic domians, one of which including a Cys-rich region, and Pik1p with LKU domain, Fq, hom2, and catalytic domain, and Stt4p with Pro-rich domain, lipid kinase unique domain, pleckstrin homology domain, and catalytic domain, overview | Saccharomyces cerevisiae |
| More | domain organization of PI4Ks: PI4KIIalpha and PI4KIIbeta with a Pro-rich and acidic region, respectively, and two catalytic domains, one of which including a Cys-rich region, and PI4KIIIalpha Pro-rich domain, NS5A binding domain, lipid kinase unique domain, pleckstrin homology domain, and catalytic domain, and PI4KIIIbeta with LKU domain, Fq, hom2, and catalytic domain and two Pro-rich regions, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Lsb6p | - |
Saccharomyces cerevisiae |
| phosphatidylinositol 4-kinase | - |
Homo sapiens |
| phosphatidylinositol 4-kinase | - |
Saccharomyces cerevisiae |
| phosphatidylinositol 4-kinase IIIbeta, | - |
Homo sapiens |
| PI4K | - |
Homo sapiens |
| PI4K | - |
Saccharomyces cerevisiae |
| PI4K230 | - |
Homo sapiens |
| PI4K55 | - |
Homo sapiens |
| PI4K92 | - |
Homo sapiens |
| PI4KIIalpha | - |
Homo sapiens |
| PI4KIIbeta | - |
Homo sapiens |
| PI4KIIIalpha | - |
Homo sapiens |
| PI4KIIIbeta | - |
Homo sapiens |
| Pik1p | - |
Saccharomyces cerevisiae |
| PtdIns 4-kinase | - |
Homo sapiens |
| PtdIns 4-kinase | - |
Saccharomyces cerevisiae |
| Stt4p | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Saccharomyces cerevisiae | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | PI4KIIalpha recruits clathrin adaptors AP1, AP3 and GGAs to the trans-Golgi network, and controls fate of endocytic vesicles, PI4KIIalpha promotes EGF receptor degradation, and supports Wnt signaling. PI4KIIIbeta regulates exit of certain cargos from the Golgi, and supports CERT-mediated ceramide transport to the trans-Golgi. PI4KIIIalpha supplies PtdIns(4,5)P2 for the plasma membrane and regulates the endoplasmic reticulum exit. Phosphatidylinositide 4-phosphate lipids are involved in viral replications. They can be used as replication platforms in the host membranes that are hijacked by RNA viruses including the endoplasmic reticulum, Golgi apparatus, trans-Golgi network, endosomes, plasma membrane and mitochondrial outer membrane. Viral replication machinery is assembled on these platforms as a supramolecular complex and PtdIns4P lipids regulate viral RNA synthesis, detailed overview. Throughout infection, the viral replication membrane platforms contain high levels of the host enzyme phosphatidylinositol 4-kinase IIIbeta, PI4KIIIbeta, that generates PtdIns4P at these membranes. PI4KIIIbeta or PI4KIIIalpha, independently from making PtdIns4P lipids, can also serve as scaffolds to recruit other host proteins to the replication platform | Homo sapiens |
| physiological function | Stt4p supplies PtdIns(4,5)P2 for the plasma membrane, regulates Pkc1 pathways and sphingolipid synthesis, and is required for cell wall integrity, Stt4p controls mitotic checkpoints. Pik1p is essentially required for late Golgi to plasma membrane secretion, and involved in cytokinesis and translation.Lsb6p can partially reverse Stt4p but not Pik1p defects, and regulates actin binding and movements of endosomes. Phosphatidylinositide 4-phosphate lipids are involved in viral replications. They can be used as replication platforms in the host membranes that are hijacked by RNA viruses including the endoplasmic reticulum, Golgi apparatus, trans-Golgi network, endosomes, plasma membrane and mitochondrial outer membrane. Viral replication machinery is assembled on these platforms as a supramolecular complex and PtdIns4P lipids regulate viral RNA synthesis, detailed overview. Throughout infection, the viral replication membrane platforms contain high levels of the host enzyme Pik1p, that generates PtdIns4P at these membranes | Saccharomyces cerevisiae |
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