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Literature summary for 2.7.1.67 extracted from

  • Jovic, M.; Kean, M.J.; Szentpetery, Z.; Polevoy, G.; Gingras, A.C.; Brill, J.A.; Balla, T.
    Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, beta-glucocerebrosidase (2012), Mol. Biol. Cell, 23, 1533-1545.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
FLAG-tagged PI4KIIIbeta is stably expressed in HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PIK93
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome isoozyme PI4KIIalpha Homo sapiens 5768
-
Golgi membrane isozyme PI4KIIIbeta Homo sapiens 139
-
membrane
-
Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-kinase
-
Homo sapiens
PI4K
-
Homo sapiens

General Information

General Information Comment Organism
malfunction PI4KIIalpha knockdown causes enlarged LAMP-1-positive endosomal structures in fixed cells. Acute depletion of phosphatidylinositol 4-phosphate in the Golgi causes accumulation of LIMP-2 in this compartment, and PI4KIIIbeta is responsible for controlling the exit of LIMP-2 from the Golgi. In contrast, depletion of PI4KIIalpha blocks trafficking at a post-Golgi compartment, leading to accumulation of LIMP-2 in enlarged endosomal vesicles. PI4KIIalpha depletion also causes secretion of missorted GBA into the medium, which is attenuated by limiting LIMP-2/GBA exit from the Golgi by PI4KIIIbeta inhibitors, overview Homo sapiens
physiological function distinct phosphatidylinositol 4-kinases play important roles at multiple steps in the trafficking pathway of the LIMP-2/GBA complex. The phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, beta-glucocerebrosidase, overview. Catalytic activity of PI4KIIIbeta in Golgi exit of the LIMP-2/GBA complex, which is followed by PI4KIIalpha-mediated trafficking to lysosomes. PI4KIalpha is involved in post-Golgi trafficking of LIMP-2 along the degradative pathway Homo sapiens