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Literature summary for 2.7.1.67 extracted from
- Mammalian phosphatidylinositol 4-kinases (2003), IUBMB Life, 55, 59-65.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| PI4K230 DELTA1-1189 | deletion mutant with 97000 Da compared to wild-type enzyme of 230000 Da, the enzyme is stable but activity is not detectable | Homo sapiens |
| PI4K230 DELTA1-1427 | deletion mutant with 68000 Da compared to wild-type enzyme of 230000 Da, the enzyme is stable but activity is not detectable | Homo sapiens |
| PI4K230 DELTA1-1531 | deletion mutant with 56000 Da compared to wild-type enzyme of 230000 Da, the enzyme is stable but activity is not detectable | Homo sapiens |
| PI4K230 DELTA1-872 | deletion mutant with 130000 Da compared to wild-type enzyme of 230000 Da, the enzyme is stable, 0.048 mM/mg*min compared to 0.058 mM/mg*min for the wild-type enzyme | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | neuronal cells | Mus musculus | 5737 | - |
| cytoplasm | neuronal cells | Homo sapiens | 5737 | - |
| cytoplasm | neuronal cells | Rattus norvegicus | 5737 | - |
| cytoplasm | neuronal cells | Bos taurus | 5737 | - |
| membrane | PI4K230 is distributed evenly on membranes that are ultra structurally cisterns of the rough endoplasmic reticulum, outer membranes of mitochondria, multivesicular bodies and are in close vicinity of synaptic contacts | Mus musculus | 16020 | - |
| membrane | PI4K230 is distributed evenly on membranes that are ultra structurally cisterns of the rough endoplasmic reticulum, outer membranes of mitochondria, multivesicular bodies and are in close vicinity of synaptic contacts | Homo sapiens | 16020 | - |
| membrane | PI4K230 is distributed evenly on membranes that are ultra structurally cisterns of the rough endoplasmic reticulum, outer membranes of mitochondria, multivesicular bodies and are in close vicinity of synaptic contacts | Rattus norvegicus | 16020 | - |
| membrane | PI4K230 is distributed evenly on membranes that are ultra structurally cisterns of the rough endoplasmic reticulum, outer membranes of mitochondria, multivesicular bodies and are in close vicinity of synaptic contacts | Bos taurus | 16020 | - |
| nucleolus | enzyme PI4K230 | Mus musculus | 5730 | - |
| nucleolus | enzyme PI4K230 | Homo sapiens | 5730 | - |
| nucleolus | enzyme PI4K230 | Rattus norvegicus | 5730 | - |
| nucleolus | enzyme PI4K230 | Bos taurus | 5730 | - |
| nucleus | enzyme form PI4K92 | Mus musculus | 5634 | - |
| nucleus | enzyme form PI4K92 | Homo sapiens | 5634 | - |
| nucleus | enzyme form PI4K92 | Rattus norvegicus | 5634 | - |
| nucleus | enzyme form PI4K92 | Bos taurus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | Mus musculus | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |  |
| ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | Rattus norvegicus | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | Bos taurus | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
| neuron | - |
Rattus norvegicus | - |
| neuron | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Bos taurus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | PI4K92 is a key enzyme regulating Golgi disintegration/reorganization during mitosis probably via phosphorylation by cyclin-dependent kinases on well-defined sites. PI4K55 is involved in the production of second messengers, diacylglycerol and inositol 1,4,5-triphosphate at the plasma membrane, moreover, in the endocytotic pathway in the cytoplasm | Bos taurus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
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