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Literature summary for 2.7.1.67 extracted from

  • Yamakawa, A.; Takenawa, T.
    Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain (1988), J. Biol. Chem., 263, 17555-17560.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 0.1-1.0% w/v, stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ADP 0.5 mM, 77.4% inhibition Rattus norvegicus
AMP 0.5 mM, 70.8% inhibition Rattus norvegicus
cAMP 0.5 mM, 10.8% inhibition Rattus norvegicus
CDP 0.5 mM, 72.8% inhibition Rattus norvegicus
CTP 0.5 mM, 38% inhibition Rattus norvegicus
GTP
-
Rattus norvegicus
quercetin 1 mM, 36% inhibition Rattus norvegicus
SDS 0.05%, complete Rattus norvegicus
UTP 0.5 mM, 69% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.115
-
phosphatidylinositol pH 7.4, 30°C Rattus norvegicus
0.15
-
ATP pH 7.4, 30°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound to Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ the enzyme requires 5-20 mM Mg2+ or 1-2 mM Mn2+ Rattus norvegicus
Mn2+ the enzyme requires 5-20 mM Mg2+ or 1-2 mM Mn2+ Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000
-
1 * 76000, SDS-PAGE Rattus norvegicus
80000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.143
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
?
GTP + 1-phosphatidyl-1D-myo-inositol no activity Rattus norvegicus GDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 76000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
broad Rattus norvegicus