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Literature summary for 2.7.1.67 extracted from
- Separation and identification of two phosphatidylinositol 4-kinase activities in bovine uterus (1989), Biochem. Biophys. Res. Commun., 160, 202-209.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | enzyme type I is stimulated at low concentrations, enzyme type II is stimulated by concentrations of Triton up to 1% | Bos taurus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine | enzyme type I is resistant, enzyme type II is inhibited | Bos taurus | |
| Mn2+ | above 0.5 mM | Bos taurus | |
| Triton X-100 | enzyme type I is inhibited at concentrations above 0.2% | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
ATP | pH 8.3, enzyme type II | Bos taurus | |
| 0.25 | - |
ATP | pH 8.3, enzyme type I | Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | divalent cation required, maximal activity at 5-10 mM | Bos taurus | |
| Mn2+ | optimal concentration for enzyme type I is 1-20 mM, optimal activity for enzyme type II is 0.5 mM | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
enzyme type II, gel filtration | Bos taurus |
| 200000 | - |
enzyme type I, gel filtration | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| phosphatidylinositol 4-kinase type I and type II | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Bos taurus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | optimal stability of enzyme type I and type II | Bos taurus |
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Release 2023.1 (January 2023)
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