Literature summary for 2.7.1.60 extracted from

Harazi, A.; Becker-Cohen, M.; Zer, H.; Moshel, O.; Hinderlich, S.; Mitrani-Rosenbaum, S.
The interaction of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and alpha-actinin 2 is altered in GNE myopathy M743T mutant (2017), Mol. Neurobiol., 54, 2928-2938.

Search for more literature for 2.7.1.60

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3)pS and HEK-293T cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
M743T	the mutation, which is associated with GNE myopathy, has a 10fold lower binding affinity to alpha-actinin 2 than the intact enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + N-acyl-D-mannosamine	Homo sapiens	-	ADP + N-acyl-D-mannosamine 6-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y223	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + N-acyl-D-mannosamine	-	Homo sapiens	ADP + N-acyl-D-mannosamine 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
GNE	-	Homo sapiens
UDP-GlcNAc 2-epimerase/ManNAc kinase	-	Homo sapiens
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	-	Homo sapiens

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Release 2023.1 (January 2023)